Acetaminophen is an antipyretic and analgesic drug that can be bought and used without prescription worldwide. Morse developed this drug for the first time in 1878, and Von Mering used it clinically in 1887. Paracetamol (the international name of the medicine in Europe) and Acetaminophen (N-acetyl-p-aminophenol, APAP, the international name of this medicine in the US) are both the official names of a chemical compound. Further studies are needed to evaluate the molecular mechanism of this hyper analgesic effect. It is suggested that this compound can enhance analgesic effects of APAP and eventually lead to a reduction in acetaminophen dose. ConclusionĬo-administration of NAC with APAP can improve the antinociceptive effect of APAP. The treatments had no adverse effect on liver enzymes and oxidative stress. Moreover, NAC treatment exhibited an antinociceptive effect in 60 and 90 min, per se. The results showed that NAC’s concurrent administration with APAP, dose-dependently increased APAP analgesic effects ( p< 0.0001). The antinociceptive effect was recorded by measurement of latency period on a hot plate in 30, 60, and 90 min after administrations. All administrations were done orally for once. Methodsįorty-eight male Sprague-Dawley rats (12–14 weeks) randomly divided into six equal groups control, APAP (received 300 mg/kg APAP), NAC (received 600 mg/kg NAC) and APAP+ NAC groups that received simultaneously 300 mg/kg APAP with 200–600 mg/kg NAC (AN200, AN400, AN600). The NAC-APAP drug formulation may demonstrate the stranger antinociceptive effect. Thus, this study was aimed to investigate the analgesic effect of co-administration of NAC and acetaminophen in male rats. However, no study has focused on the efficacy of these drugs’ concurrent administration on probable enhancing therapeutic outcomes. Up to now, interventive therapy with n-acetylcysteine (NAC) has been considered as a gold-standard treatment for APAP overdose. Acetaminophen (APAP) induced hepatotoxicity is a clinically important problem.
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